The recommended dose of XPHOZAH is 30 mg before the first and last meals of the day.​ If a patient doesn’t eat breakfast and their first meal of the day is lunch, they should take XPHOZAH just before lunch, as that is their first meal of the day. They should take XPHOZAH again just before dinner.​

While there is no guidance in the label on time between doses, patients should not take 2 doses at the same time. If a dose is missed, skip the missed dose and take the next dose at the regular time.​

Do not take XPHOZAH right before a hemodialysis session as patient may experience diarrhea.

INDICATION XPHOZAH (tenapanor) 30 mg BID is indicated to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy.

IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS XPHOZAH is contraindicated in: Pediatric patients under 6 years of age Patients with known or suspected mechanical gastrointestinal obstruction

WARNINGS AND PRECAUTIONS Diarrhea Patients may experience severe diarrhea. Treatment with XPHOZAH should be discontinued in patients who develop severe diarrhea.

MOST COMMON ADVERSE REACTIONS Diarrhea, which occurred in 43-53% of patients, was the only adverse reaction reported in at least 5% of XPHOZAH-treated patients with CKD on dialysis across trials. The majority of diarrhea events in XPHOZAH-treated patients were reported to be mild-to-moderate in severity and resolved over time, or with dose reduction. Diarrhea was typically reported soon after initiation but could occur at any time during treatment with XPHOZAH. Severe diarrhea was reported in 5% of XPHOZAH-treated patients in these trials.